Please conduct research targeting Toll-like receptor (TLR) signaling pathways.
The purpose of the research is to understand:
the relationship of how and why TLR signaling pathways may affect innate immune response in the COVID-19 virus. Additionally, do drugs in the quinoline family in combination with macrolides shut off COVID-19 cell protein synthesis, cause apoptosis and release interferons (Mistry,2018) and (El-Zayat,Sibaii & Mannaa,2019)?
According to many experts, TLR’s are known to activate anti- microbial, fungal, viral and protozoan activities and produce pro-inflammatory cytokines in acute disease and modulate TLR’s in auto-immune and chronic disease (Zhu & Mohan, 2010), and (Loiarro, Riggerio & Sette, 2010).